Ingredients

Mr. Happy is formulated by Dr. Geo Espinosa, who is the Medical Director of XY Wellness, and was originally designed for his patients dealing with normal, age-related, general health concerns.

This ground-breaking formula is designed to deliver antioxidant support and boost your nitric oxide levels, and by doing so to support improvements in your cardiovascular health, mental and physical energy levels, cellular health, sexual health, general mood, and stress levels.*

 

improved sexual function

L-CITRULLINE

This amino acid converts into L-arginine, which is essential to the production of nitric oxide (NO), but unlike L-arginine, L-citrulline metabolizes slowly enough to stimulate sustained NO secretion. Healthy levels of NO are critical to good health, as NO acts as a vaso-dilator that sends signals to your blood vessels to relax which in turn increases blood flow and decreases blood pressure. Increased blood flow brings with it a number of benefits, such as improved oxygen transfer, improved brain function, increased energy levels, improved stamina, faster post-exertion recovery, and improved sexual function for both men and women. * 

natural anti-inflammatory

EPIMEDIUM GRANDIFLORUM

This botanical, also known as Horny Goat Weed (nope, not kidding), is a potent antioxidant that is rich in a flavanoid called Icariin, which research suggests supports a number of benefits, including boosting NO levels in the body, promoting blood flow to the pelvic region, increasing energy levels while inhibiting fatigue, supporting reductions in inflammation, and supporting healthy immune system function. *

improved immune system function

RHODIOLA ROSEA

This botanical is a potent antioxidant and adaptogen that has been associated with a wide range of health benefits, including the improved mental performance, improved mood and mental outlook, increased energy levels and stamina, reduced fatigue levels, reduced stress levels, improved immune system function, and improved cardiovascular health. *

how to naturally increase testosterone

POLYGONUM CUSPIDATUM

This botanical is a rich source of Resveratrol, which is a potent antioxidant, which research suggests is associated with a wide range of benefits, including improvements in circulation, vision, and sexual health. Studies suggest that resveratrol may help to ward off atherosclerotic changes associated with imbalanced cholesterol, and to improve NO circulation, blood testosterone levels, erection quality, and sperm count and motility. *

natural anti inflammatory

POMEGRANATE

This botanical is a potent antioxidant is rich in anthocyanin, which is a flavonoid that studies suggest promotes a range of benefits including enhancing NO bioavailability, promoting arterial health and blood flow, balancing of cholesterol levels, improving glucose metabolism, improving cardiovascular health, reducing inflammation, and improving blood flow to the pelvic region which in turn supports improved sexual health and function. * 

The Science

  • 1Ning H, Xin ZC, Lin G, Banie L, Lue TF, Lin CS. Effects of icariin on phosphodiesterase-­‐5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology 2006;68:1350–4.  3 
  • 2Dell'Agli M, Galli GV, Dal Cero E, Belluti F, Matera R, Zironi E, Pagliuca G, Bosisio E. Potent inhibition of human phosphodiesterase-­‐5 by icariin derivatives. J Nat Prod 2008;71:1513–7. 
  • 3Shindel, A. W., Xin, Z.-­‐C., Lin, G., Fandel, T. M., Huang, Y.-­‐C., Banie, L., Breyer, B. N., Garcia, M. M., Lin, C.-­‐S. and Lue, T. F. (2010), Erectogenic and Neurotrophic Effects of Icariin, a Purified Extract of Horny Goat Weed (Epimedium spp.) In Vitro and In Vivo. The Journal of Sexual Medicine, 7: 1518–1528
  • 4Oral L-­‐citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Source: Urology [0090-­‐4295] Cormio yr:2011 vol:77 iss:1 pg:119 -­‐22 
  • 5Darbinyan V, Kteyan A, Panossian A, et al. Rhodiola rosea in stress induced fatigue—a double blind cross-­‐over study of a standardized extract SHR-­‐5 with a repeated low-­‐dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000;7:365-­‐371.
  • 6Spasov AA, Wikman GK, Mandrikov VB, et al. A double-­‐blind, placebo-­‐controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-­‐5 extract on the fatigue of students caused by stress during an examination period with a repeated low-­‐dose regimen. Phytomedicine. 2000;7:85-­‐89.
  • 7Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-­‐5 rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003;10:95-­‐105.
  • 8Olsson EM, von Schéele B, Panossian AG.A randomised, double-­‐blind, placebo-­‐controlled, parallel-­‐group study of the standardised extract shr-­‐5 of the roots of Rhodiola rosea in the treatment of subjects with stress-­‐related fatigue. Planta Med. 2009 Feb;75(2):105-­‐12. Epub 2008 Nov 18. 
  • 9Soner, et al. Evaluation of vascular smooth muscle and corpus cavernosum on hypercholesterolemia. Is resveratrol promising on erectile dysfunction? Int. J Imp Res, Volume: 22   Issue: 4   Pages: 227-­‐233   DOI: 10.1038/ijir.2010.8   Published: JUL-­‐AUG 2010 
  • 10Fukuhara S, Tsujimura A, Okuda H, Yamamoto K, Takao T, Miyagawa Y, Nonomura N, Okuyama A. Vardenafil and resveratrol synergistically enhance the nitric oxide/cyclic guanosine monophosphate pathway in corpus cavernosal smooth muscle cells and its therapeutic potential for erectile dysfunction in the streptozotocin-­‐induced diabetic rat: preliminary findings. J Sex Med. 2011 Apr;8(4):1061-­‐71. doi: 10.1111/j.1743-­‐6109.2010.02193.x. Epub 2011 Jan 26.
  • 11Shin S, Jeon JH, Park D, Jang MJ, Choi JH, Choi BH, Joo SS, Nahm SS, Kim JC, Kim YB. Trans-­‐Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo. Arch Pharm Res. 2008 Jan;31(1):83-­‐7. 
  • 12Forest CP, Padma-­‐Nathan H, Liker HR.; Efficacy and safety of pomegranate juice on improvement of erectile function in male patients with mild to moderate erectile dysfunction: a randomized, placebo-­‐controlled, double-­‐blind, crossover study. Int J Impot Res. 2007 Nov-­‐Dec;19(6):564-­‐7. Epub 2007 Jun 14. 
  • 13Shiota A, Hotta Y, Kataoka T, Morita M, Maeda Y, Kimura K.Oral l-­‐Citrulline Supplementation Improves Erectile Function in Rats with Acute Arteriogenic Erectile Dysfunction. J Sex Med. 2013 Jul 11 
  • 14Moinard C, Cynober L. Citrulline: a new player in the control of nitrogen homeostasis. J Nutr. 2007 Jun;137(6 Suppl 2):1621S-­‐1625S.
  • 15Cynober L, Moinard C, De Bandt JP.The 2009 ESPEN Sir David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game? Clin Nutr. 2010 Oct;29(5):545-­‐51. 
  • 16Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev. 2006 Fall-­‐Winter;24(3-­‐4):275-­‐90.
  • 17Hecker M, Sessa WC, Harris HJ, Anggård EE, Vane JR. The metabolism of L-­‐arginine and its significance for the biosynthesis of endothelium-­‐derived relaxing factor: cultured endothelial cells recycle L-­‐citrulline to L-­‐arginine. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8612-­‐6. 
  • 18Al-­‐Jarallah A, Igdoura F, Zhang Y, Tenedero CB, White EJ, MacDonald ME, Igdoura SA, Trigatti BL. The effect of pomegranate extract on coronary artery atherosclerosis in SR-­‐BI/APOE double knockout mice. Atherosclerosis. 2013 May;228(1):80-­‐9. 
  • 19C. P. Forest, H. Padma-­‐Nathan, and H. R. Liker, “Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-­‐controlled, double-­‐blind, crossover study,” International Journal of Impotence Research, vol. 19, no. 6, pp. 564–567, 2007. 
  • 20C. B. Stowe, “The effects of pomegranate juice consumption on blood pressure and cardiovascular health,” Complementary Therapies in Clinical Practice, vol. 17, no. 2, pp. 113–115, 2011. 
  • 21Aviram M, Dornfeld L. 2001. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 158:195 
  • 22Davidson MH, Maki KC, Dicklin MR, Feinstein SB, Witchger M, et al. 2009. Effects of consumption of pomegranate juice on carotid intima-­‐media thickness in men and women at moderate risk for coronary heart disease. Am. J. Cardiol. 104:936–42 
  • 23Rock W, Rosenblat M, Miller-­‐Lotan R, Levy AP, Elias M, Aviram M. 2008. Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-­‐density lipoprotein and stimulates its catalytic activities. J. Agric. Food Chem. 56:8704–13 
  • 24Sahebkar A.Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-­‐analysis of randomized controlled trials. Nutr Rev. 2013 Oct 1. 
  • 25Frankel EN, Waterhouse AL, Kinsella JE. Inhibition of human LDL oxidation by resveratrol. Lancet. 1993;341:1103–1104.
  • 26Xia N, Daiber A, Habermeier A, et al. Resveratrol reverses endothelial nitric-­‐oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther. 2010;335:149–154. 
  • 27Cherniack EP, Troen BR. Resveratrol: effects on lipids and cardiovascular risk. Curr Cardiovasc Risk Rep. 2013;7:9–16.
  • 28Zhang H, Zhang J, Ungvari Z, et al. Resveratrol improves endothelial function: role of TNFα and vascular oxidative stress. Arterioscler Thromb Vasc Biol. 2009;29:1164–1171. 
  • 29Chen, X.J.; Ji, H.; Zhang, Q.W.; Tu, P.F.; Wang, Y.T.; Guo, B.L.; Li, S.P. A rapid method for simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and ultra-­‐performance liquid chromatography. J. Pharm. Biomed. Anal. 2008, 46, 226-­‐235.
  • 30Zhao, F.; Tang, Y.Z.; Liu, Z.Q. Protective effect of icariin on DNA against radical-­‐induced oxidative damage. J. Pharm. Pharmacol. 2007, 59, 1729-­‐1732.
  • 31Liu, Z.Q.; Luo, X.Y.; Sun, Y.X.; Wu, W.; Liu, C.M.; Liu, S.Y. The antioxidative effect of icariin in human erythrocytes against free-­‐radical-­‐induced haemolysis. J. Pharm. Pharmacol. 2004, 56, 1557-­‐1562. 
  • 32Pratico, D. Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows. Ann. N. Y. Acad. Sci. 2008, 1147, 70-­‐78.
  • 33Nie, J.; Luo, Y.; Huang, X.N.; Gong, Q.H.; Wu, Q.; Shi, J.S. Icariin inhibits beta-­‐amyloid peptidesegment 25-­‐35 induced expression of beta-­‐secretase in rat hippocampus. Eur. J. Pharmacol. 2010, 626, 213-­‐218. 

Recommended Use

Since Mr. Happy is a daily supplement, its benefits build over time. You should expect to start noticing these benefits during your second week.

LOADING PERIOD

During your initial 15-day Loading Period, take 2 capsules, twice per day.

MAINTENANCE

Thereafter, you can switch to the Regular Dosage of 2 capsules per day, meaning that at Regular Dosage each bottle contains a full month’s supply.

Get more Rooster back into your life! Act now; be Mr. Happy.*